BISPECIFIC ANTIGEN MOLECULE FOR LYSIS OF TUMOR CELLS, METHOD FOR PREPARING F(AB')2 FRAGMENT OF BISPECIFIC ANTIGEN MOLECULE, MONOCLONAL ANTIBODY (VERSIONS), PHARMACEUTICAL PREPARATION, PHARMACEUTICAL KIT FOR LYSIS OF TUMOR CELLS (VERSIONS), METHOD OF LYSIS OF TUMOR CELLS EX VIVO IN AUTOGENOUS BONE MARROW TRANSPLANTATION

摘要

FIELD: biotechnology, medicine, oncology, pharmacy. SUBSTANCE: invention relates to bispecific molecule of antigen that recognizes antigen of lymphocytes CD2 and any variable tumor antigen. Except for, invention relates to two novel monoclonal antibodies designated as AICD2.M1 and AICD2.M2. Combination of these antibodies one of that at least represents bispecific antigen molecule can be used in pharmaceutical preparation or kit successively for therapy and diagnosis of tumors. EFFECT: improved preparing method, valuable medicinal properties of preparation and kit. 13 cl, 9 dwg, 12 ex