锌卟啉修饰的环糊精纳米分子管道

摘要

To obtain well-organized nanosupramolecular assemblies,the cyclodextrin-based molecular tube containing azide groups was synthesized by the hydrophobic interaction betweenα-cyclodextrins and polyethylene glycol,in which several cyclodextrin u-nits were penetrated into the polymer backbone.Water-soluble cyclodextrin-based nanosupramolecular assembly was further con-structed by the Cu(I)-catalyzed [3 + 2]cycloaddition reaction with propargyl Zn-porphyrin.The molecular weight distribution, the content of azido-α-CD,and the modification degree of Zn-porphyrin were measured by gel permeation chromatography and UV/Vis spectroscopy,and the morphology of the molecular tube was investigated by atomic force microscopy.The introduction of porphyrin groups can endow the cyclodextrin nanotube with fluorescent property and the formation of nanotube backbone can further enhance the thermostability.%为了获得规则有序的纳米超分子组装体，通过环糊精与聚乙二醇的疏水相互作用，将多个α-环糊精穿入高分子的骨架上，制备出含有叠氮基的环糊精纳米管道。进一步通过亚铜催化的[3＋2]环加成反应将炔基锌卟啉修饰到环糊精纳米管壁上，制备了含有锌卟啉的水溶性环糊精线性纳米超分子组装体。采用凝胶渗透色谱、紫外－可见光谱方法探究了纳米分子管道的分子量分布、叠氮基的环糊精的含量和锌卟啉分子的修饰度，并采用原子力显微镜测定了分子管道的组装形貌。卟啉的引入赋予了环糊精良好的荧光性能，而纳米管道骨架结构的形成有助于进一步提高环糊精组装体的热稳定性。