无创正压通气治疗AECOPD并早期肺性脑病的临床分析

摘要

Objective To investigate the clinical effect of noninvasive positive pressure ventilation (NPPV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with early pulmonary encephalopathy. Methods A retrospective analysis was made of 30 cases of AECOPD combined with early pulmonary encephalopathy undergone NPPV. The blood gas analysis changes and clinical changes before treatment and after 2 h and 24 h of treatment were observed. Results Among the 30 cases in the group, there were 3 cases undergone invasive ventilation treatment instead, 2 treatment abandoning cases, and 25 cases (83%) with obvious improvement in blood gas analysis. Compared with indexes before treatment, arterial partial pressure of carbon dioxide levels were decreased (P<0.05), arterial partial pressure of oxygen levels were increased (P<0.05), and pH was increased (P<0.05). Conclusion The application of BIPAP ventilator assisted ventilation in the treatment of AECOPD combined with early pulmonary encephalopathy has precise effect, and it can rapidly improve the gas exchange in AECOPD.%目的：探讨无创正压通气(NPPV)对慢性阻塞性肺疾病急性加重(AECOPD)并早期肺性脑病患者的临床疗效。方法30例呼吸内科行无创通气的AECOPD并早期肺性脑病患者,观察治疗前及治疗2、24 h后的血气分析变化及临床变化。结果本组30例患者中3例改行有创通气治疗,2例放弃治疗,25例(83%)血气分析结果明显改善,与治疗前比较；动脉血二氧化碳分压水平降低(P<0.05),动脉血氧分压水平升高(P<0.05), pH值升高(P<0.05)。结论应用BIPAP呼吸机辅助通气治疗AECOPD并早期肺性脑病疗效确切,能迅速改善AECOPD的气体交换。