酮咯酸氨丁三醇不同途径给药对骨折患者术前疼痛的影响

摘要

Objective To investigate influence by different administration routes of ketorolac tromethamine on preoperative pain of fracture patients. Methods A total of 186 fracture patients were randomly divided into groups A, B and C, with 62 cases in each group. They received respectively intravenous drip, intramuscular injection, and oral administration for medication. Static and dynamic visual analogue scale (VAS), body indexes, and analgesic effect were observed and recorded before and after drug administration in the three groups for comparative analysis. Results Groups A and B had all better VAS scores in each time points after drug administration than group C (P<0.05). HR of group A in 10 and 30 min after administration and that of group B in 30 min after administration were all obviously lower than that of group C at the same time points (P<0.05). Group A had lower incidences of nausea and emesis than groups B and C after administration (P<0.05). Conclusion Intravenous drip of ketorolac tromethamine shows better clinical effect than the other two administration routes. This method can show sedative, anti-inflammatory effect.%目的：探讨酮咯酸氨丁三醇不同途径给药对骨折患者术前疼痛的影响。方法随机将186例骨折患者分为 A、B、C 三组，每组62例，分别采取静脉滴注、肌内注射、口服三种方式进行临床给药，观察并记录三组患者在给药前和给药后不同时段的动、静态疼痛视觉模拟评分(VAS)、各类机体指标以及镇痛效果，并对其进行分析对比。结果A、B 组给药后各时点 VAS 评分均优于 C 组(P<0.05)；A 组患者给药后10 min 及30 min、B 组给药后30 min HR 明显低于同时点 C 组(P<0.05)；A 组给药后恶心、呕吐发生率低于 B、C 组(P<0.05)。结论当酮咯酸氨丁三醇以静脉滴注的方式给药时，其临床效果明显优于其他给药途径，可有效发挥出其镇痛、抗炎的作用。