一清胶囊对痤疮丙酸杆菌及表皮葡萄球菌的体外抑菌作用研究

摘要

OBJECTIVE: To study the bacteriostatic action of Yiqing capsule against propionibacterium acnes and staphyl-ococcus epiderrnidis in vitro. METHODS: Propionibacterium aches and staphylococcus epidermidis were cultured by mi-croplating method and routine plating, and the bacteriostatic action of different concentration of Yiqing capsule and its main components against propionibacterium aches and staphylococcus epidermidis were determined by measuring their MICs. RE-SULTS: The MICs of Yiqing capsule and Scutellaria baicalensis extractum against propionibacterium acnes and staphylococ-cus epiderrnidis were 0.98 mg·mL~(-1) and 1 mg·mL~(-1),respectively, whereas the MICs of Radix et Rhizoma Rhei and Rhizoma Coptidis Scutellaria extractum against propionibacterium acnes and staphylococcus epidermidis were 1.96 mg·mL~(-1) and 1 mg·mL~(-1),respectively. CONCLUSION: Yiqing capsule showed satisfactory bacteriostatic action against the major pathogenic bacteria of acne.%目的:研究一清胶囊对痤疮丙酸杆菌及表皮葡萄球菌的体外抑菌作用.方法:采用微量板、常规平皿法分别对痤疮丙酸杆菌、表皮葡萄球菌进行培养并观察不同浓度一清胶囊及其主要成分的抑菌效果,分别求出其最小抑菌浓度(MIC).结果:一清胶囊对痤疮丙酸杆菌及表皮葡萄球菌的MIC分别为0.98、1 mg·mL~(-1),黄芩浸膏的MIC分别为0.98、1 mg·mL~(-1),而大黄黄连浸膏的MIC分别为1.96、1 mg·mL~(-1).结论:一清胶囊对痤疮主要致病菌有较好的体外抑菌效果.