注射用单唾液酸四己糖神经节苷脂钠近红外特征谱段相关系数模型的建立

摘要

Objective:To construct characteristic spectral correlation coefficient model for monosialotetrahexosyl ganglioside sodi-um injections ( GM1 injections) from different manufacturers by near-infrared ( NIR) diffuse reflectance spectroscopy to provide refer-ence for the rapid test. Methods:NIR spectral correlation coefficient model for 9 batches of GM1 injections from 2 manufacturers was constructed, and the accuracy and transitivity of the model was validated. Results: The correlation coefficient model can accurately distinguish the samples from the 2 manufacturers. Conclusion:The method is simple, fast and reliable, and has the potential to be em-ployed in the mobile laboratory to identify GM1 injections.%目的：运用近红外(NIR)漫反射光谱法建立不同厂家注射用单唾液酸四己糖神经节苷脂钠(注射用GM1)的特征谱段相关系数模型，为该品种药品(国产)快速检验提供依据。方法：对国内2个厂家的共9个批次注射用GM1进行研究，通过扫描其近红外光谱，建立注射用GM1的特征谱段相关系数模型，并验证模型的准确性和可传递性。结果：建立的相关系数模型能够准确区分2个厂家的样品。结论：本方法简便、快捷、可靠，可对国内不同厂家生产的注射用GM1进行快速的初步定性分析，适用于药品检验车的快速无损检测。