聚合物胶束在经皮给药系统中的应用

摘要

目的: 综述聚合物胶束作为药物载体在经皮传递系统中的应用进展.方法: 根据国内外发表的最新文献,对聚合物胶束的制备方法、促进皮肤渗透的机制、释药过程及其在经皮给药系统中的应用进行分析与讨论.结果: 聚合物胶束具有增加难溶性药物的溶解度,促进药物的经皮吸收等作用,作为药物载体在经皮传递系统的应用越来越广泛.结论: 聚合物胶束可作为药物载体被广泛用于经皮给药系统的研究中,具有较好的发展前景.%Objective: To review the application of polymeric micelles as the vehicles in transdermal delivery systems.Methods: Based on the recently published papers, the researches of preparation, penetration mechanism, drug release and application of polymeric micelles in transdermal delivery systems were classified and summarized.Results: Polymeric micelles were extensively applied as drug vehicles due to the ability of solubilization and transdermal absorption enhancement.Conclusion: Polymeric micelles can be used as promising vehicles in transdermal delivery systems, which show a good application prospect.