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Ophthalmic drug delivery system using polymer micelle

机译:使用聚合物胶束的眼科给药系统

摘要

The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to positerior tissues of the eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.
机译:当前的情况是,药物难以到达眼球的后组织,例如脉络膜和视网膜,结果是难以在这些区域中治疗疾病。因此,如何有效地递送药物是重要的。已经发现,将药物有效地递送到眼球的后组织,例如脉络膜和视网膜,特别是其中已经发生血管化的那些药物,可以通过全身给药,特别是其中掺入有药物的聚合物胶束的静脉内给药来实现。此外,已经发现当将光敏物质用作药物并进行PDT时,脉络膜新血管可被有效地阻塞,从而可用于治疗与年龄有关的黄斑变性。

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