Spin‐labeling of polymeric micelles and application in probing micelle swelling using EPR spectroscopy

Pan Yanxiong; Neupane Sunanda; Farmakes Jasmin; Liu Bingqing; Sun Wenfang; Yang Zhongyu

摘要

ABSTRACT > Polymer structure and conformational dynamics are essential to polymer macroscopic properties, but are challenging to probe. We report here a synthetic pathway to chemically add a nitroxide moiety onto block polymers in a mild, aqueous environment and demonstrate its use in a series of polymeric micelles using Electron Paramagnetic Resonance (EPR) spectroscopy. The micelles were characterized with several analytical approaches and EPR findings were in general consistent with other approaches. Upon exposure to organic solvents, the line shape changes reflected the micelle swelling and EPR spectral simulations revealed structural information of the swelled micelles. The label introduced via our method can be cleaved and replaced with other probes to report different information site‐specifically. The mild conditions facilitate the future use of EPR in solving biopolymer problems. In combination with other labeling approaches, one can perform polymer spin labeling with different chemistry, so that various information about polymers can be obtained site‐specifically. ? 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017 , 55 , 1770–1782 </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>抽象</ title> >聚合物结构和构象动态对聚合物至关重要宏观特性，但探究尖锐。我们在此报告一种合成途径，用于将硝基氧化物部分在温和的，水性环境中的嵌段聚合物中加入嵌段聚合物上，并用电子顺笔共振（EPR）光谱证明其在一系列聚合物胶束中使用。用几种分析方法表征胶束，并且EPR发现一般与其他方法一致。在暴露于有机溶剂时，线形状变化反映了胶束溶胀和EPR光谱仿真揭示了膨胀胶束的结构信息。通过我们的方法引入的标签可以被切割并用其他探针替换，以报告不同的信息网站 - 具体。温和条件有助于未来使用EPR在解决生物聚合物问题方面。结合其他标记方法，可以用不同的化学进行聚合物旋转标记，从而可以获得有关聚合物的各种信息 - 具体地，可以获得位点。还2017年Wiley期刊，Inc.J.Minon。 SCI。，B部分：聚合物。物理。 2017 </ b>， 55 </ i>，1770-1782 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-35627/'>《Journal of Polymer Science, Part B. Polymer Physics 》</a> <b style="margin: 0 2px;">|</b><span>2017年第23期</span><b style="margin: 0 2px;">|</b> <span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pan Yanxiong&option=202" target="_blank" rel="nofollow">Pan Yanxiong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Neupane Sunanda&option=202" target="_blank" rel="nofollow">Neupane Sunanda;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Farmakes Jasmin&option=202" target="_blank" rel="nofollow">Farmakes Jasmin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Bingqing&option=202" target="_blank" rel="nofollow">Liu Bingqing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Wenfang&option=202" target="_blank" rel="nofollow">Sun Wenfang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Zhongyu&option=202" target="_blank" rel="nofollow">Yang Zhongyu;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> <p>Department of Chemistry and BiochemistryNorth Dakota State UniversityFargo North Dakota 58108;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/1185.html" title="高分子化学（高聚物）">高分子化学（高聚物） ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=EPR spectroscopy&option=203" rel="nofollow">EPR spectroscopy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ESR/EPR&option=203" rel="nofollow">ESR/EPR;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=micelles&option=203" rel="nofollow">micelles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=polymer spin labeling&option=203" rel="nofollow">polymer spin labeling;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=spectral simulation&option=203" rel="nofollow">spectral simulation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=swelling&option=203" rel="nofollow">swelling;</a> </p> <div class="translation"> 机译：EPR光谱;ESR / EPR;胶束;聚合物旋转标签;光谱仿真;肿胀; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025810949.html">Spin‐labeling of polymeric micelles and application in probing micelle swelling using EPR spectroscopy</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Pan Yanxiong&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Pan Yanxiong,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Neupane Sunanda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Neupane Sunanda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Farmakes Jasmin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Farmakes Jasmin,</a> <a href="/journal-foreign-35627/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Polymer Science, Part B. 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