不同浓度脂肪乳注射液在全合一营养液中的稳定性研究

摘要

To study the stability of all - in - one nutrition made by fat emulsion of 10% ,20% and 30% concentraiton. To prepare all-in-one nutrition of 10% ,20% end 30% fat emulsion according io a same prescription. Sampling from all-in-one nutrition after 0,2,6.12,24,36.48h under 25 X'. Respectively. Then to detect particle diameter and Zeta potentials.which display stability of the samples. At the same time, to add some suclan yellow to the samples to observe whether emulsion breaking happens. Results No group showed emulsion breaking after 48 h under 25 °C. Particle diameter and Zeta potentials of samples were in safety range for injection. Statistics analysis of the data showed no significant differences between samples at different lime point. Conclusion During observation period-all-in-one nutrition made by fat emulsion of 10%,20% and 30% concentraiton are all stable.%目的 研究10%,20%,30%脂肪乳注射液在全合一营养液中的稳定性.方法 将不同浓度的脂肪乳注射液按照相同的处方配制成全舍一营养液,在25℃静置0,2,6,12,24,36,48 h后取样,用激光动态光散射仪检测营养液中乳粒直径和油相表面与水相存在的电位差(ξ)的大小,同时向营养液中添加脂溶性染料苏丹红,定时观察是否发生破乳现象.结果 48 h后,3组全合一营养液均发生破乳,脂肪乳注射液乳粒大小、Zeta电位也均在安全、稳定范围内,统计学分析显示各时间点无明显差异.结论 观察期内10%,20%.30%脂肪乳制剂在全合一营养液中均稳定.