Objective To investigate the status of serious adverse drug reaction (ADR) in our hospital to reduce its incidence and the extent of injure. Methods ADR cases reports in our hospital from January 2004 to April 2011 were collected and statistically analyzed according to the questionnaires. Results Of collected 1 259 ADR cases, 154 cases were serious ADR. Most of them were resulted from intravenous administration, which accounted for 64. 29%. Serious ADR affected digestive, circulatory, urinary and reproductive and other systems. The involved suspicious drugs were 93 varieties 12 categories. Anti - infectives were the most common (51. 15% ). Among the 154 cases of serious ADR occurred from immediately beginning of drug administration to after 282 d after administration. Partial serious ADR could be related with irrational drug use, such as too large single dose, too lager total doses, too fast administration and improper combination drug use. In addition, 12 serious ADR cases may be related to irrational drug uses, including overhigh single drug dose, over dose, and so on. Conclusion Understanding the main adverse reactions of drugs, rational drug use and targeted observation and monitoring are conducive to reduce the occurrence and harmfulness of serious ADR.%目的 分析医院住院患者麻醉药品的使用情况及用药趋势,为其科学管理和合理应用提供参考.方法 统计2008年至2010年住院部各种麻醉药品使用情况,分别对其用药频度、用药金额进行比较.结果 麻醉药品消耗金额逐年增加,但所占百分比逐年下降;枸橼酸芬太尼注射液(0.1 mg)用量最大,枸橼酸舒芬太尼注射液用量上升趋势最大.结论 麻醉药品的应用基本合理,用法用量、用药总量以及用途等均能严格按照国家相关规定执行.
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