普罗布考联合阿托伐他汀对急性脑梗死康复期患者血管内皮细胞功能及生活质量的影响

摘要

目的：探讨阿托伐他汀联合普罗布考治疗急性脑梗死患者的疗效及其对血清血管内皮细胞功能及生活质量的影响。方法将100例脑梗死急性发作患者按随机数字表法均分成对照组和试验组，对照组给予阿托伐他汀治疗，试验组给予阿托伐他汀联合普罗布考治疗，对比分析两组患者的疗效。结果试验组研究对象的总有效率为96．00%，优于对照组的62．00%，差异有统计学意义（ P<0．05）。试验组患者治疗后基质金属蛋白酶（MMP）－2为（84．42±13．21）ng/mL、MMP－9为（176．38±19．85）ng/mL，明显优于对照组的（110．31±14．42）ng/mL和（211．25±21．21）ng/mL，差异有统计学意义（ P<0．05）。试验组患者治疗后Barthel指数评分为（67．11±11．01）分、Spitzer指数评分为（42．18±5．05）分，明显高于对照组的（46．17±10．08）分和（31．85±4．51）分，差异有统计学意义（ P<0．05）。结论阿托伐他汀联合普罗布考治疗急性脑梗死疗效显著，临床意义重大。%Objective To analyze the effect of atorvastatin combined with probucol on serum vascular endothelial cells and fibrinolysis function in patients with acute cerebral infarction. Methods 100 cases of cerebral infarction patients with acute attack were equally divided into the control group and the experimental group according to the random number table method. The control group was given Objective To analyze the effect of atorvastatin combined with probucol on serum vascular endothelial cells and fibrinolysis function in patients with acute cerebral infarction. Methods 100 cases of cerebral infarction patients with acute attack were equally divided into the control group and the experimental group according to the random number table method. The control group was given atorvastatin therapy, and the experimental group was given atorvastatin combined with probucol probucol treatment. The treatment effect of the two groups were analyzed. Results The total effective rate of the experimental group was 96. 00%, which significantly higher than 62. 00% of the control group ( P < 0. 05 ) . After treatment, the MMP-2 was ( 84. 42 ± 13. 21 ) ng/mL and MMP-9 was ( 176. 38 ± 19. 85 ) ng/mL in the experimental group, which were significantly better than ( 110. 31 ± 14. 42 ) ng/mL and ( 211. 25 ± 21. 21 ) ng/mL in the control group ( P < 0. 05 ) . The Barthel index score was ( 67. 11 ± 1. 101 ) and the Spitzer index score was ( 42. 18 ± 5. 05 ) in the experimental group, which were significantly higher than ( 46. 17 ± 10. 08 ) and ( 31. 85 ± 4. 51 ) in the control group ( P < 0. 05 ) . Conclusion Atorvastatin combined with probucol in the treatment of the patients with acute cerebral infarction has obvious efficacy and has great clinical significance.