目的：探讨还原型谷胱甘肽钠( GSH )治疗小儿急性感染性疾病致肝功能损害的临床疗效及安全性。方法选择急性感染性疾病致肝功能损害的患儿100例，随机分为观察组与对照组，各50例。其中对照组给予常规治疗，包括应用抗生素抗感染、护肝等，观察组在常规治疗的基础上给予GSH治疗，比较两组患儿治疗1周有效率，肝功能指标改善情况、恢复正常时间及并发症发生率。结果观察组患儿治疗有效率为98．00%，高于对照组的86．00%，差异有统计学意义（ P0．05）。结论应用GSH治疗小儿急性感染性疾病致肝功能损害，可有效提高治疗效果，缩短康复时间，安全性较高。%Objective To analyze the clinical efficacy and safety of reduced glutathione sodium ( GSH ) in the treatment of liver function damage caused by acute infectious diseases in children. Methods 100 cases of children with liver function damage caused by acute infectious diseases were randomly divided into observation group and control group, 50 cases in each group. The control group was given conventional treatment, including antibiotic resistant infection, liver protection and so on; the observation group was treated with GSH treatment on the basis of the routine treatment. The effective rates of the two groups of children after 1 week of treatment, index of liv-er function improvement, recovery time and the incidence of complications were compared. Results The effective rate of the observation group was 98. 00%, which was higher than 86. 00% of the control group, the difference was statistically significant ( P 0. 05 ) . Conclusion GSH in the treatment of liver function damage in children caused by acute infectious disease can effectively improve the treatment effect, shorten the recovery time and has high security.
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