Objective To observe the intervention effect of metformin for treating weight gain induced by olanzapine in first-episode female patients with schizophrenia. Methods Totally 70 female inpatients with schizophrenia were randomly divided into the interventiongroup and the control group, 35 cases in each group. The intervention group was given metformin combined with olanzapine, while the control group was given olanzapine. The changes in body weight, body mass index ( BMI ) , fasting blood glucose ( FBG ) and treatment emergent symptom scale ( TESS ) scores were compared between the two groups at baseline and after 8 weeks, all assessments were performed with blind manipulation by psychiatric staffs. Results After 8 weeks of treatment, 64 cases ( 91. 43% ) were completed, and there was no difference in the rate of abscission between the two groups ( P > 0. 05 ) . There were significant difference in body weight [( -1.7±3.1)kg vs.(0.6±3.2)kg],BMI[( -0.6±2.1)kg/m2 vs.(1±2.6)kg/m2],FBG[( -0.1±0.1)mmol/L vs.(0.1± 0. 3)mmol/L] between intervention group and control group( P 0.05);干预组和对照组体质量相比[(-1.7±3.1)kg比(0.6±3.2)kg],BMI相比[(-0.6±2.1)kg/m2比(1±2.6)kg/m2]和FBG相比[(-0.1±0.1)mmol/L比(0.1±0.3)mmol/L],差异均有统计学意义(P<0.05);对照组体质量增加3例,干预组恶心3例.结论 二甲双胍对奥氮平所致首发精神分裂症女性患者体质量增加的干预疗效佳,且安全性好.
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