降钙素原联合超敏C反应蛋白用于手足口病继发细菌感染性疾病早期诊断临床评价

摘要

目的 探讨血清降钙素原(PCT)联合超敏C反应蛋白(hs-CRP)用于早期诊断手足口病继发细菌感染性疾病的价值.方法 回顾性分析2015年1月至2016年12月医院儿科收治的150例手足口病患儿的临床资料.按出院诊断结果,分为单纯手足口病组(对照组,97例)和手足口病继发细菌感染组(观察组,53例),另选取医院体检的健康儿童作为健康对照组(健康组,30例).检测PCT和hs-CRP水平,通过受试者工作曲线(ROC)分析.结果 治疗前血清PCT和hs-CRP水平,观察组显著高于对照组和健康组(P0.05).PCT和hs-CRP联合检测诊断的曲线下面积(AUC)为0.899,敏感度为0.810,效果均优于PCT和hs-CRP单独检测(P 0. 05). The AUC of PCT combined with hs-CRP for early diagnosis of bacterial infec-tions of hand,foot and mouth disease was 0. 899,and the sensitivity was 0. 810,the effect was superior to PCT and hs-CRP alone de-tection( P < 0. 05). Conclusion The serum levels of PCT and hs-CRP were significantly increased in children with bacterial infec-tions of hand,foot and mouth disease,and the combined diagnosis of PCT and hs-CRP is important for early diagnosis of the disease.