降钙素原、超敏C反应蛋白及白细胞计数在儿科感染性疾病早期诊断中的价值

摘要

ObjectiveTo investigate the value of procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and white blood cell count (WBC) in early diagnosis of pediatric infectious diseases.Methods There were 377 children with diagnosed infectious diseases, 62 cases of them with severe bacterial infection as severe bacterial infection group, 194 cases with mild bacterial infection as mild bacterial infection group, and 121 cases with virus infection as virus infection group. Control group contained 45 healthy children in physical examination center. Venous blood of the four groups was taken for PCT, hs-CRP, and WBC detection before drug administration, and the resultswere statistically analyzed.ResultsThe severe bacterial infection group had obviously higher levels of PCT and hs-CRP than the mild bacterial infection group, virus infection group and the control group. Their difference had statistical significance (P<0.05). The mild bacterial infection group had higher levels of PCT and hs-CRP than the virus infection group and the control group, and their difference also had statistical significance (P<0.05). The severe bacterial infection group and mild bacterial infection group had higher WBC than the virus infection group and the control group, and their difference had statistical significance (P<0.05). ConclusionPCT, hs-CRP and WBC contain certain clinical value in early diagnosis of pediatric infectious diseases, and PCT has high sensibility and specificity for bacterial infection, especially for severe bacterial infection.%目的：探讨降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞计数(WBC)在儿科感染性疾病早期诊断中的价值。方法377例确诊为感染性疾病患儿，其中重症细菌感染62例患儿为重症细菌感染组，轻症细菌感染194例患儿为轻症细菌感染组，病毒感染121例患儿为病毒感染组，对照组为体检中心健康体检儿童45例。四组用药前抽取静脉血同时进行PCT、hs-CRP、WBC测定，并对其结果进行统计分析。结果重症细菌感染组患儿的PCT、hs-CRP测定值明显高于轻症细菌感染组、病毒感染组及对照组，差异均有统计学意义(P<0.05)；轻症细菌感染组PCT、hs-CRP明显高于病毒感染组及对照组，差异均有统计学意义(P<0.05)；重症细菌感染组、轻症细菌感染组的WBC高于病毒感染组及对照组，差异有统计学意义(P<0.05)。结论PCT、hs-CRP、WBC在儿科感染性疾病早期诊断中有一定的临床价值， PCT在细菌感染特别是重症细菌感染中有较高的敏感性和特异性。