目的 了解某地区小儿药物中毒发生情况及其相关危险因素.方法 选取2009年至2016年就诊的药物中毒患儿和其他疾病患儿各163例,发放问卷收集相关信息,采用多因素Logistic回归分析等方法进行分析.结果 2009年至2016年该地区的小儿药物中毒率呈升高趋势;男童所占比例显著高于女童,农村显著高于城镇(P<0.05);小儿中毒的发生率与年龄呈显著负相关(r=-0.877,P=0.001).中毒药物中镇静催眠类药物占比最高(19.02％);中毒原因中误服占比最高(43.56％).经单因素、多因素分析,文化程度[OR=1.030,95％CI(1.015,1.072)],家庭药品未严格管理[OR=1.129,95％CI(1.101,1.163)],以及家长用药知识缺乏[OR=1.812,95％CI(1.435,2.192)]为影响小儿药物中毒发生的主要危险因素.结论 小儿药物中毒发生例数不断升高,男童和低龄组儿童是高发群体,主要为误服,家长文化程度、家庭药品未严格管理和用药知识缺乏为主要危险因素.%Objective To understand the incidence and related risk factors of drug poisoning in children in a certain area.Methods Totally 163 children with drug poisoning and 163 children with other diseases from 2009 to 2016 in our hospital were selected,the related information was collected by the questionnaire and analyzed by multiple factor Logistic regression analysis.Results From 2009 to 2016,the rate of drug poisoning in children increased in the area,the proportion of boys was significantly higher than that of girls,the proportion of rural areas was significantly higher than that of urban areas(P < 0.05),and the incidence of drug poisoning in children was significantly negatively correlated with age(r= -0.877,P=0.001).The proportion of sedative hypnotic drugs in poisoned drugs was the highest(19.02％),the proportion of accidental poisoning in the cause of drug poisoning was the highest (43.56％).By the analysis of single and multiple factors,cultural level [ OR=1.030,95％ CI ( 1.015,1.072)],lacking of strict manage-ment of family medicine [ OR=1.129,95％ CI ( 1.101,1.163)] and parents lacked of knowledge of medication [ OR=1.812,95％ CI ( 1.435,2.192)] were the main risk factors for the incidence of drug poisoning in children.Conclusion The cases of drug poisoning in children is increasing,the boys and children in the younger age are high-risk groups.The main cause of drug poisoning was acci-dental poisoning,the main risk factors were the parents′ culture level,lacking of strict management of the family medicine and lacking of knowledge of medication.
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