人表皮生长因子受体(human epidermal growth factor receptor 2, HER-2)高表达被视为预后不良的重要预测因素，但随着抗HER-2靶向治疗药物曲妥珠单抗的问世以及化疗联合靶向治疗的应用，其预后逐步得到了改善。新辅助疗法因可作为“体内药敏”试验的特殊优势，成为早期可手术乳腺癌综合治疗的一种新的选择模式。近年来，新一代的抗HER-2靶向药物和治疗方法层出不穷，而在验证其疗效方面，新辅助疗法提供了一个重要的研究平台。现对HER-2过表达乳腺癌新辅助化疗的相关临床试验结果进行分析和解读，并对新近开展的多项针对HER-2过表达乳腺癌的新辅助靶向治疗研究作一综述。%The overexpression of human epidermal growth factor receptor 2 (HER-2) is generally considered as an signiifcant predictor of poor prognosis, but the outcome has been rewritten with the appearance and application of the HER-2 targeted monoclonal antibody trastuzumab and chemotherapy plus targeted therapy. For the superiority of acting as "in vivo susceptibility” test, neoadjuvant chemotherapy has become a new comprehensive treatment mode for operable breast cancer. And it has also provided an important approach to investigate the effectiveness of newly appeared targeted therapy. We focused more on reviewing and analyzing the results of clinical trials related to preoperation chemotherapy and the latest studies in HER-2 positive breast cancer in this article.
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