Fas-670G>A和Fasl-844T>C基因多态性与肺癌易感性关系研究

摘要

Background and purpose:Lung cancer is one of the leading causes of cancer death in the world. The aim of this study was to evaluate whether Fas-670 G>A and Fasl-844 T>C polymorphisms were associated with the risk of lung cancer.Methods:Data from 400 lung cancer patients with speciifc histological diagnosis were collected from 2010 to 2015. Meanwhile, data from matched healthy controls with the same gender and ±5 years were also collected. The genotypes of Fas-670 G>A and Fasl-844 T>C polymorphisms were determined by TaqMan lfuorescent probe method, and the results were analyzed using SPSS 16.0 software.Results:A total number of 386 cases and 394 controls were successfully genotyped. Compared with AA genotypeofFasgene, the GA and GG genotype carriers had no signiifcantly increased risk of lung cancer.The OR values were 1.05 (95%CI: 0.77-1.44) and 0.77 (95%CI: 0.81-1.99) respectively. Compared with TT genotype ofFasl gene, the CT and CC genotype carriers had signiifcantly increased risk of lung cancer. The OR values were 1.37 (95%CI: 1.01-1.86) and 1.74 (95%CI: 1.09-2.77), respectively. Conclusion:Fasl-844 T>C polymorphism may be involved in lung cancer risk but not Fas-670 G>A polymorphism.%背景与目的：肺癌是全球肿瘤相关性死亡的主要病因之一。该研究旨在探索Fas-670 G>A和Fasl-844 T>C基因多态性与肺癌易感性关系。方法：2010—2015年，共收集400例具有明确病理诊断的肺癌病例，同时按照同性别，选取年龄±5岁进行匹配健康对照，采用TaqMan荧光探针法进行基因分型检测。对实验结果，采用SPSS 16.0软件进行统计分析。结果：共386例肺癌患者和394例健康对照者分型成功，与Fas基因的AA基因型携带者相比，GA和GG基因型携带者肺癌发病风险无显著性增加，OR值分别为1.05(0.77~1.44)和1.27(0.81~1.99)，与Fasl基因的TT基因型携带者相比，CT和CC基因型携带者患肺癌的风险显著升高，调整年龄、性别和吸烟状态后，OR值分别为1.37(1.01~1.86)和1.74(1.09~2.77)。结论：Fasl-844 T>C多态性可能与肺癌易感性有关，Fas-670 G>A多态性可能与肺癌易感性无关。