Investigation on the association between estrogen β receptor gene polymorphisms and the susceptibility of adolescent idiopathic scoliosis

摘要

It has been detected that the ER α Xbal polymorphism might be associated with the development of adolescent idiopathic scoliosis (AIS). And, some literatures reported that ER β polymorphism is associated with bone mineral density. It remained unclear whether ER β polymorphism is associated with the susceptibility of AIS patients. Blood samples were obtained from 288 patients with AIS and 232 healthy adolescent. Anthropometric parameters of AIS group including age, body height, weight, arm span, age of menarche, Cobb angle and Risser sign were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze ER β gene distributions of AIS group and control group. The frequency ER β genotype was no significantly difference between AIS patients and control group. In AIS patients, the expression of Rr genotype in patients whose menarche age was ≥12 years was higher than those whose menarche age was <12 years (P<0.05), but there were no significant association of the genotype distribution with regards to body height, BMI, arm span, Cobb angle and Risser sign. There was no significantly association between ER β gene and the susceptibility of AIS. Rr genotype maybe play a important role in the progression of AIS patients.