CIK细胞免疫治疗对转移性肾细胞癌患者免疫功能的影响

摘要

Objective To study the effect of cytokine-induced killer(CIK) cells immunotherapy on immunological func-tion of patients with metastatic renal cell carcinoma.Methods A total of 70 patients with metastatic renal cell carcino-ma were randomly divided into 2 groups, 35 cases of the treatment group were added with CIK cells, while the control group was given IL-2 and IFN-α, detected the immunological function of 70 cases including the levels of CD3+, CD4+, CD8+T cells, ratio of CD4+/CD8+, one week before therapy of CIK cells and one month week after treatment. Results The levels of CD3+、CD4+cells, ratio of CD4+/CD8+in peripheral blood of patients with renal cancer of two groups were much higher than those before therapy (P<0.05), the levels CD8+ was lower after treatment, there were significant changes (P<0.05). Conclusion CIK cells immunotherapy can enhance the immunological function of patients with meta-static renal cell carcinoma.%目的：观察CIK细胞免疫治疗对转移性肾癌患者免疫功能的影响。方法选取2010~2012年收治的转移性肾癌患者，在常规治疗措施的基础上联合应用CIK细胞免疫方法进行临床治疗，治疗3个疗程后，监测治疗前后CD3+、CD4+、CD8+、CD4+/CD8+比值等免疫功能指标，进行统计学分析。结果治疗后患者外周血中CD3+、CD4+、CD8+、CD4+/CD8+水平优于治疗前(P<0.055)。结论采用悦陨运细胞免疫治疗能有效提高转移性肾癌患者的免疫功能。