纤溶系统与一氧化氮在冠心病心绞痛发病中的临床意义

摘要

Objective To study the clinical significance of FIB rinolysis and nitric oxide(NO) in coronary heart disease patients wiht angina pactoris. Methods Levels of plasmin plasminogen activator inhibitor-1 (PAI-1), tissue-type plasminogen activator(t-PA) ,plasminogen, Fibrinogen(FIB) and NO in 63 patients with unstable angina pactoris(UA) ,29 patients with stable angina paetoris(SA) were measured, and 20 normal cases as control group were analyzed in the same ways. Results Levels of PAI-1, FIB in UA patients were significantly higher than in SA patients and in normal cases, those in patients with heart events were also significantly higher than those without heart events; Levels of t-PA,NO in UA patients were significantly lower than in SA patients and in normal cases, those in patients with heart events were also significantly lower than those without heart events; There were no significant differances among of all groups in levels of Pig. Conclusion The abnormality of Fibrinolysis function and decrease of NO levels might be associated with heart events, and the abnormal ityin UA patients was more evident than that in SA patients.%目的 探讨并研究纤溶系统与一氧化氮在冠状动脉粥样硬化性心脏病(冠心病)心绞痛发病中的临床价值.方法 对冠心病组68例不稳定型心绞痛(UA)患者和29例稳定型心绞痛(SA)患者体内纤溶酶原激活物抑制剂-1(PAI-1)、组织型纤溶酶原激活剂(t-PA)、纤溶酶原以及纤维蛋白原和一氧化氮水平进行检测,并与对照组20例健康人的上述指标进行对照.结果 冠心病组UA患者体内PAI-1、纤维蛋白原水平明显高于冠心病组SA患者和对照组,有心绞痛事件发生组上述指标也明显高于无心绞痛事件发生组(P<0.05或P<0.01);冠心病组UA患者体内t-PA及一氧化氮水平明显低于冠心病组SA患者和对照组,有心绞痛事件发生组也明显低于无心绞痛事件发生组(P<0.05或P<0.01);纤溶酶原值各组差异均无统计学意义(P0.05).结论 冠心病患者心绞痛事件发生可能与纤溶系统功能异常和一氧化氮水平降低相关,并且UA患者纤溶系统功能异常和一氧化氮水平降低程度较SA患者更为严重.