探讨儿童外周血异型淋巴细胞增多的病原学及临床动态变化特点

摘要

目的 探讨儿童外周血异型淋巴细胞增多的病原学及临床动态变化特点.方法 对60例外周血液涂片异型淋巴细胞>2%的患儿,应用聚合酶链反应(PCR)法检测EB病毒DNA、巨细胞病毒DNA及乙肝表面抗原病毒DNA;采用咽拭子分泌物PCR法检测支原体DNA;酶联免疫吸附试验检测腺病毒IgM抗体、FB病毒IgM抗体;同时进行血液涂片及瑞氏染色,对异型淋巴细胞进行记数并按病程进行动态观察.结果 49例(81.7%)患儿被检出有病毒或支原体感染;EB病毒、巨细胞病毒感染引起的异型淋巴细胞增多所占百分比较高,恢复正常所需时间亦较长,其他感染所占百分比较低,恢复正常所需时间较短.结论 引起儿童外周血异型淋巴细胞增多的病原除EB病毒、巨细胞病毒、支原体、腺病毒外,其他感染亦会引起其增多,其中以EB病毒所占比例最多;不同的疾病中出现的异型淋巴细胞数量有很大的差异性,并随病程的发展而发生动态变化.%Objective To observe the etiology and the dynamic changes of increased peripheral atypical lymphocytes in child. Methods Sixty-one children was enrolled. EBV-DNA,CMV-DNA,Hepatitis B-DNA were detected by PCR test. Results Forty nine of the samples(82% ) were infected by virus or mycoplasma, EBV、CMV. Other infection causes were rare. Conclusion In addition to EBV, CVB, CMV, MP, AdV infection can cause lymphocytes incensement.