lymphocyte expansion composition; method of preparing a population of clinically relevant lymphocytes; immunotherapy for treating or preventing an infectious disease, a cancerous disease, or an autoimmune disease in a mammal; composition for use; kit for use in immunotherapy, in particular for the treatment of a cancerous disease; clinically relevant lymphocyte obtained by a method; and clinically relevant lymphocyte population obtained by a method

摘要

The present invention relates to a lymphocyte expansion composition comprising at least two types of cytokines selected from interleukin 2 (il-2), interleukin 15 (il-15) and interleukin 21 (il-21). further relates to a method of preparing a clinically relevant lymphocyte population, comprising the steps of: obtaining a body sample from a mammal, in particular a tissue sample or body fluid sample, comprising at least one lymphocyte and optionally separating cells in the body sample, in vitro body sample culture to expand and / or stimulate lymphocytes in the sample wherein the culture comprises the use of il-2, il-15 and / or il-21, and optionally determining the presence of clinically relevant lymphocyte in the cultured sample. The present invention also relates to immunotherapy and the clinically relevant lymphocyte population.