食管鳞癌中血管内皮生长因子和基质金属蛋白酶7的表达及其意义

摘要

目的 探讨血管内皮生长因子(VEGF)和基质金属蛋白酶7(MMP-7)在食管癌中的表达及意义.方法 用免疫组织化学染色的方法检测50例食管鳞癌标本及30例取非瘤正常食管组织标本中VEGF与MMP-7的表达.结果 食管癌组织中MMP-7和VEGF表达阳性率分别为70%(42/60)、75%(45/60),在癌旁正常食管组织中阳性表达率分别为13.3%(4/30)、26.6%(8/30),2组差异均有统计学意义(P<0.05).MMP-7和VEGF的表达与淋巴结转移和TNM分期有关,即有淋巴结转移和中晚期的食管癌组织中,MMP-7和VEGF的阳性表达率明显高于无淋巴结转移和早期的食管癌组织(P<0.05).结论 VEGF和MMP-7与食管癌的发生、发展密切相关.%Objective To investigate the expression of Vascular endothelial grouth factor( VEGF) and Ma-trix metalloproteinase-7 (MMP-7) in esophageal carcinoma and other esophageal disease. Methods The protein ex-pression of VEGF and MMP-7 in 60 cases with esophageal squamous cell carcinoma 30 cases of normal tissue were determined by immunohistochemical strep tavidinperoxidase method. Results The expression of VEGF and MMP-7 increased obviously in esophageal carcinoma. The decreased VEGF and MMP-7 expression was correlated with lymph node metastasis infiltration deph and TNM stage, the expression of MMP-7 was inversely correlated with the expression of VEGF in esophageal carcinoma. Conclusion VEGF and MMP-7 are associated with the growth of e-sophageal carcinoma and may play an important role in the metastasis of carcinogenesis of esophagus.