普外科围手术期抗感染药物使用调查分析

摘要

Objective To investigate the usage of perioperative anti-infective in general surgery in our hospital and to provide references for clinical rational usage of drugs.Methods We randomly selected 259 cases in general surgery in 2010,according to the ministry of health regarding the “ clinical use of antibiotics guiding principles” in 2004,and the “the clinical use and management of antibiotics” in 2009.Results The rate of antimicrobial drug used in general surgery was 95.8％ (248/259) ; the rate in cleaning surgical was 94.1％ (176/187); the rate in clean-contaminated surgery and contaminated surgery was 100.0％ (61/61,72/72).The mean operation time was 2.1 h.94.4％ (234/248) of antimicrobial agents were used unreasonably.The top five antimicrobial drugs were cefoxitin,mezlocillin,five water cefazolin,cefotiam and levofloxacin.Conclusion There is irrational use of perioperative antimicrobial drug in general surgery.%目的 调查我院普外科围手术期抗感染药物使用情况,分析其合理性,为临床合理用药提供参考依据.方法 随机抽取2010年我院普外科手术病历259例,根据2004年卫生部《抗菌药物临床应用指导原则》和2009年《关于抗菌药物临床应用管理有关问题的通知》,调查分析围手术期抗感染药物的使用情况.结果 我院普外科围手术期抗感染药物使用率为95.8％ (248/259),清洁手术抗感染药物使用率为94.1％ (176/187),清洁-污染手术和污染手术抗感染药物使用率均为100.0％ (61/61、72/72)；中位手术时间为2.1h,抗感染药物中位时间为5d；不合理用药率为94.4％(234/248)；抗感染药物使用频率前5位的是:头孢西丁、美洛西林、五水头孢唑啉、头孢替安、左氧氟沙星.结论 我院普外科围手术期抗感染药物使用存在一定不合理现象,如用药指征不明确、用药时间长、选择药物不适宜等.