医院2010-2012年抗真菌药使用分析

摘要

目的 评价2010-2012年抗真菌药物使用情况.方法 利用计算机对各药出库数量和金额数据进行统计排序.采用世界卫生组织推荐的限定日剂量(DDD)作为药物利用研究的测定单位,调查解放军第三○九医院2010-2012年抗真菌药销售金额、销售量,采用金额分析法、用药频度(DDDs)分析法对抗真菌药的销售金额、年DDDs和日均费用等进行统计分析.结果 2010-2012年本院抗真菌药物的年销售总金额呈明显下降趋势,2011年销售总金额(11 381 151元)较2010年销售总金额(13 756 650元)下降17.3％,2012年销售总金额(11 349 923元)较2010年销售总金额(13 756 650元)下降17.5％,DDDs同步性较好.临床使用占主导地位的是三唑类及棘白菌素类抗真菌药,2010-2012年销售总金额位列前3位的是注射用米卡芬净钠、氟康唑注射液及注射用伏立康唑;用药频度位列前3位的是伊曲康唑胶囊、氟康唑注射液及氟康唑胶囊.结论 本院抗真菌药物应用合理、管理完善,疗效确定、价格适中的抗真菌药具有良好的发展趋势.%Objective To evaluate the application of the antifungal agents from 2010 to 2012; to provide the references for clinical management and rational use of drugs.Methods The utilization data such as consumption sum and quantity of Antifungal agents in our hospital from 2010 to 2012 were statistically analyzd from the consumption sum,annual defined daily dose statistic(DDDs) and defined daily cost(DDC) by methods of consumption analysis and DDDs analysis.Results The consumption sum of antifungal agents markedly reduced year by year,the consumption sum of the year 2011 (11 381 151 yuan) decreased 17.3％ compared with the year 2010 (13 756 650 yuan),the consumption sum of the year 2012 (11 349 923 yuan) decreased 17.5％ compared with the year 2010(13 756 650 yuan),and the DDDs showed good synchronism.triazole antifungal agents and echinocandins were the dominant antifungal agents in our hospital.The top 3 of the drug consumption sum were micafungin,fluconazol and voriconazole; the top 3 of the drug DDDs were itraconazole capsules,fluconazole injection and fluconazole capsules.Conclusion the application of the hospital Antifungal agents is reasonable,the management is perfect,the antifungal agents which possess confirm curative effect and moderate price have good prospect.but there are some irrational drug uses.