氨溴索静滴结合阿奇霉素序贯治疗小儿支原体肺炎的效果观察

摘要

Objective To investigate the clinical effect of ambroxol intravenous drip combined with azithromycin sequential therapy for mycoplasma pneumonia with child. Methods 80 cases were adopted ambroxol intravenous drip 1.2mg/(kg·d),then the observation group were used azithromycin,the first intravenous infusion 10mg/(kg·d),1 time a day,continuous treatment 5d,then with oral,10mg/(kg·d),1 time a day,continuous treatment two weeks,the control group were only used azithromycin 10mg/(kg·d) intravenously.Then clinical symptoms,treatment adverse reactions and intravenous fluids discomfort were compared. Results The patients fever disappeared,disappeared wheezing,coughing and rales disappeared disappearance time in observation group were faster than control group (P<0.05),the gastrointestinal discomfort and impaired renal function ratios were significantly lower than control group (P<0.05),the observation group did not appear one case with necrosis,while the control group appeared two cases,the observation group occurred after infusion local swelling and needles prolapse cases were less than control group (P<0.05). Conclusion Ambroxol intravenous drip combination with azithromycin sequential therapy for mycoplasma pneumonia with child can rapidly improve the clinical symptoms of mycoplasma pneumonia and reduce the treatment side effects and improve the treatment compliance,so it is an effective manner for mycoplasma pneumonia with child.%目的：探讨氨溴索静滴结合阿奇霉素序贯治疗小儿支原体肺炎的临床效果。方法选择80例患儿，所有患儿均采用氨溴索1.2mg/（kg·d）静滴，观察组使用阿奇霉素，先静脉滴注10mg/（kg·d），每日1次，连续治疗5d，后口服，10mg/（kg·d），每日1次，连续治疗2周，对照组仅使用阿奇霉素10mg/（kg·d）静脉滴注。比较两组临床症状消失时间、治疗不良反应及静脉输液不适情况。结果观察组患者发热消失、喘息消失、咳嗽消失及啰音消失均显著快于对照组（P＜0.05），观察组出现胃肠道不适及肝肾功能受损的比率均显著低于对照组（P＜0.05），观察组未出现1例局部坏死情况，而对照组则出现2例，观察组发生输液后局部红肿和针头脱出的情况显著少于对照组（P＜0.05）。结论氨溴索静滴结合阿奇霉素序贯治疗，能较快的改善小儿支原体肺炎患者临床症状，减少治疗不良反应，是提高治疗依从性的有效方法。