血清5'-核苷酸酶在肝炎分型诊断上的应用价值

摘要

ObjectiveTo investigate the clinical value of serum 5-NT in the diagnosis of hepatitis type. Methods This study selected 190 cases of hepatitis patients and 40 normal patients in our hospital from March 2013 to December 2014, we used the automatic biochemical analyzer to detect the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ- glutamine (GGT) ,5'-nucleotide enzyme(5-NT) in all patients. All the results were statistically analyzed and we compared the differences of 5-NT in different populations. Results The 5-NT level of acute hepatitis, chronic hepatitis, severe hepatitis, liver cirrhosis and healthy patients were:(350 ± 260)U / L, (149 ± 121)U / L, (305 ± 241)U / L, (156 ± 132)U / L, (19 ± 10)U / L. Compared with healthy patients, the 5-NT level of acute hepatitis, chronic hepatitis, severe hepatitis, liver cirrhosis patients were significantly increased, and the difference has statistically significance. Compared with chronic hepatitis and liver cirrhosis patients, the 5-NT level of acute hepatitis and severe hepatitis patients were higher.Conclusion The combination of liver common tests and 5-NT detection is important for the diagnosis of various types of hepatitis.%目的：探讨血清5'-核苷酸酶指标在肝炎分型诊断中的临床应用价值。方法本研究选取了2013年3月～2014年12月我院收治的190例肝炎患者和40例正常患者作为研究对象，应用全自动生化仪测定所有人的血清谷草转氨酶（AST）、谷丙转氨酶（ALT）、碱性磷酸酶（ALP）、γ-谷氨酰氨转肽酶（GGT）及5'-核苷酸酶的水平，并对结果作统计学分析，比较在不同人群中血清5'-核苷酸酶的差异。结果急性肝炎、慢性肝炎、重型肝炎、肝炎肝硬化、健康患者的血清5'-核苷酸酶水平分别为：（350±260）U/L，（149±121）U/L，（305±241）U/L，（156±132）U/L，（19±10）U/L，与健康患者相比，急性肝炎、慢性肝炎、重型肝炎、肝炎肝硬化患者的血清5'-核苷酸酶水平明显升高，且差异具有统计学意义；与慢性肝炎患者相比，急性肝炎患者的血清5'-NT水平明显升高，与肝炎肝硬化患者相比，重型肝炎患者的血清5'-NT水平明显升高，且差异具有统计学意义。结论血清5'-核苷酸酶是各型肝炎的一项敏感的生化指标，常用肝功能检测指标联合5'-核苷酸酶检测，对各型肝炎的诊断具有重要意义。