不同剂量孕激素治疗无排卵型月经失调的临床效果分析

摘要

Objective To investigate the clinical efficacy of different doses of progestin on anovulatory menstrual disorders.Methods90 cases of anovulatory menstrual disorders from April 2012 to April 2014 in our hospital were selected.They were randomly divided into A、B、C group,30 cases in each group.They were treated with 100mg/d,200mg/d,300mg/d progestin,respectively.The clinical efficacy of the three groups were compared.Results The total effective rate of the three groups was 93.3%, 96.7%,96.7%, respectively.The total effective rate of the three groups has no statistically difference(P>0.05).The endometrial thickness before and after the treatment has no statistically difference(P>0.05).The incidence of adverse reactions of the three groups was 3.3%,13.3%,26.7%.The incidence of adverse reactions of the B,C group was significantly increased compared with A group(P<0.05).The incidence of adverse reactions of the C group was significantly increased compared with B group(P<0.05). ConclusionsThe total effective rate of different doses of progestin has no significantly difference on anovulatory menstrual disorders. However, the incidence of adverse reactions was increased as the dose increased.Low-dose progesterone should be used in the clinical treatment to reduce adverse reactions.%目的：探讨不同剂量孕激素对无排卵型月经失调的临床治疗效果。方法本研究选取了2012年4月～2014年4月我院收治的90例无排卵型月经失调患者作为研究对象，将90例患者随机分为A、B、C三组，每组各30例，分别给予三组患者100mg/d、200mg/d、300mg/d孕激素治疗，观察不同剂量孕激素对无排卵型月经失调的疗效。结果 A、B、C三组患者的治疗有效率分别为93.3%，96.7%，96.7%，三组患者治疗后的有效率相比差异无统计学意义（P＞0.05）。三组患者治疗前后的子宫内膜厚度差异无统计学意义（P＞0.05）。A、B、C三组患者的不良反应发生率分别为3.3%，13.3%，26.7%，B、C两组的不良反应发生率较A组显著提高（P＜0.05），C组的不良反应发生率较B组差异有统计学意义（P＜0.05）。结论不同剂量孕激素治疗无排卵型月经失调的疗效无明显差异，但随着剂量的升高，患者的不良反应增多，临床应尽量对患者采用低剂量孕激素治疗，以降低患者的不良反应。