Progesterone in the Field-Forward Treatment of Traumatic Brain Injury

摘要

The purpose of this pre-clinical concept award project was to develop a safe and effective field-forward treatment to reduce neuronal loss after traumatic brain injury and thereby to enhance cognitive, sensory and motor recovery. Our primary objective was to synthesize and screen new progesterone pro-drug candidates for relative solubility that are more potent, stable and easily administered by immediate corporal injection than natural progesterone under battlefield conditions. We also sought to determine whether the prodrug would be as effective as progesterone in promoting neuroprotection after TBI. These objectives were accomplished.