普米克令舒雾化吸入治疗儿童哮喘的疗效及对血清中IL-1β和IL-12影响的研究

摘要

Objective To investigate the clinical efficacy of childhood asthma treated with Budesonide Suspension for atom-ization inhalation and study its effect on serum IL-lp and IL-12 level changes. Methods 364 patients with childhoodrnasthma were selected in our hospital from November 2010 lo December 2011, who were randomly divided into two groups. 182 patients used conventional ireaiment as the control group. On the basis of conventional treatractil.,182 patients used Budesonide Suspension (atomization inhalation, 6-10 min/Ume, 3 times/day) in the treatment as the observation group. The course of treatment was 7 d. Serum IL-1β and IL-12 level changes were compared between two groups before and after the treatment. Results After the treatment, scores of cough, wheezing, dyspnea, pulmonary wheeze in the observation group were significantly lower than those in the control group. Serum IL-1β level in the observation group was significantly lower than that in the control group, while serum IL-1β declining value in the observation group was significantly greater than that in the control group. Serum IL-12 level in the observation group was significantly lower than that in the control group, while serum IL-12 declining value in the observation group was significantly greater than that in the control group. The difference was statistically significant (P ＜ 0.05). Conclusion Budesonide Suspension atomlzatlon inhalation in the treatment of childhood asthma has obvious clinical curative effect, which can reduce serum IL-1β and IL-12 level. That cart effective regulate inflammatory environment of children patients. That is a safe and effective treatment method and worthy of clinical use.%目的 探讨普米克令舒雾化吸入佐治儿童哮喘的临床疗效及对血清中白细胞介素-1β(IL-1β)和白细胞介素-12(IL-12)水平变化的影响.方法 选取本院2010年11月～2011年12月收治的儿童哮喘患者364例,随机分为两组,采用常规治疗患儿182例为对照组,在常规治疗基础上联合使用普米克令舒(雾化吸入,6～10 min/次,3次/d,)治疗患儿182例为观察组,治疗疗程均为7 d,比较两组患儿治疗前后的血清IL-1β和IL-12水平变化情况.结果 治疗后,观察组咳嗽、喘息、呼吸困难、肺内哮鸣音评分均明显低于对照组,观察组血清IL-1β水平明显低于对照组,观察组血清IL-1β的下降值明显大于对照组,观察组血清IL-12水平明显低于对照组,观察组血清IL-12的下降值明显大于对照组,差异均有统计学意义(P<0.05).结论 普米克令舒雾化吸入佐治儿童哮喘具有显著的临床疗效,可以大幅减低患儿血清中IL-1β和IL-12水平,有效调节患儿体内的炎性环境,是一种安全有效的治疗方法,值得临床推广使用.