药物联合电针治疗对慢性精神分裂症患者细胞免疫功能的影响

摘要

目的 探讨药物联合电针治疗对慢性精神分裂症患者细胞免疫功能的影响.方法选取慢性精神分裂症患者65例(药物治疗组34例,针药治疗组31例),药物组选用氯氮平治疗,剂量150 mg/d,1次/d,每晚口服,治疗观察时间为6周.针药组除应用上述药物治疗外,每日针灸1次,并使用电针仪辅助治疗.分别于治疗前、治疗后第6周检测T淋巴细胞亚群(CD3、CD4、CD8)与白介素(IL-2、IL-6).分别施测简明精神病评定量表(BPRS)、阳性症状评定量表(SAPS)和阴性症状评定量表(SANS)以评定其精神症状.结果治疗后两组患者IL-2均较治疗前下降(P ＜ 0.05);治疗后药物合并电针治疗组IL-6水平低于药物组(P ＜ 0.01);IL-2水平低于药物组(P ＜ 0.05).治疗后药物合并电针治疗组CD4水平高于治疗前(P ＜ 0.05),也高于药物组(P ＜ 0.05).结论抗精神病治疗可以影响慢性精神分裂症患者的免疫功能,且电针合并药物组更明显.%Objective To discuss the influence of medicine combined with electro—acupuncture on the cellular immunity functions of the chronic schizophrenics. Methods 65 continuous hospitalized patients with schizophrenia were selected and randomly divided into medication group (n = 34) and medicine combined with electro-acupuncture group (n = 31). Clozapine was selected by the medication group to treat the patients. The dose was 150 mg/day and the medicine was taken orally once a day at night. The treatment observation time was 6 weeks. Except the above-mentioned medication treatment, acupuncture was also selected by the medicine combined with electro-acupuncture group one time each day and electroacupuncture apparatus was used as adjunctive therapy. Two cun needling instruments were used. Blood were taken separately before the treatment and at the end of the sixth week of the treatment; the expressions of T lymphocyte subset (CD3, CD4 and CD8) and Interleukin (IL-2 and IL-6) in blood were tested. Results The CD4 level of the electro-acupuncture group had been increased, and it was higher than that of the medication group (P < 0.05). The expression of IL-2 was decreased for both of the two treated groups (P < 0.05); Both IL-2 and IL-6 level of the electro-acupuncture group were lower than that of the medication group, significantly (P < 0.05). Conclusion The anti-psychosis treatment can influence patients' immune functions, and the effects are more obvious for the electro-acupuncture group.