MicroRNA及lncRNA在心肌纤维化中的研究进展

摘要

Myocardial fibrosis is the process of excessive accumulation of collagen fibers in myocardial tissue.In recent years,the role of non coding RNA including small RNA (miRNA) and long non-coding RNA (lncRNA),has become a hot topic.miRNA and lncRNA regulate the occurrence and development of myocardial fibrosis by activating multiple signaling pathways and mechanisms.This article reviews the mechanism and research progress of miRNA and lncRNA in myocardial fibrosis.%心肌纤维化是指心肌组织结构中胶原纤维过度积聚的过程.近年来,非编码RNA包括小RNA(miRNA)和长链非编码RNA(lncRNA)对心肌纤维化的调控作用逐渐成为研究热点.miRNA及lncRNA通过多种信号通路及机制调控心肌纤维化的发生和发展.本文对近年来miRNA和lncRNA在心肌纤维化中的机制及研究进展进行了综述.