窄谱中波紫外线治疗仪联合复方甘草酸苷治疗寻常银屑病疗效观察

摘要

Objective: To explore psoriasis vulgaris efficacy of the narrow band UVB therapy combined with compound glycyrrhizin. Methods: The study made it clear diagnosis for patients admitted to our hospital 45 patients with psoriasis vulgaris were randomly divided into experimental group with 25 cases(narrow band UVB therapy combined with compound glycyrrhizin) and control group with 20 cases(only narrow-band UVB irradiation), in order to compare and analyze the treatment effect, the incidence of adverse reactions and symptoms before and after treatment PASI score recorded. Results: The difference was not statistically significant about PASI score of patients in the experimental group and the control group before treatment(t=0.153, P>0.05). But the difference of PASI score was statistically significant between two groups of patients after treatment(t=4.675, P<0.05). The effective rate of treatment in patients of the experimental group was 92%and 75%in the control group. The adverse symptoms in the experimental group and control group were 20% and 60% respectively. The differences were statistically significant (x2=47.908, P<0.05). Conclusion: Narrow band UVB combined with compound glycyrrhizin treatment of psoriasis with respect to only a narrow band ultraviolet therapy have significant therapeutic effect, and it can effectively reduce the incidence of adverse symptoms. It is worth popularizing in clinical.%目的：探究窄谱中波紫外线治疗仪联合复方甘草酸苷治疗寻常银屑病的疗效。方法：选取明确诊断为寻常银屑病的45例患者，采用随机数字表法将其分成观察组(25例)与对照组(20例)。观察组采用窄谱中波紫外线联合复方甘草酸苷治疗；对照组单纯使用窄谱中波紫外线照射治疗。观察对比两组患者的治疗效果、不良反应症状的发生率；记录治疗前后两组患者的银屑病面积与严重性指数(PASI)评分，并进行对比分析。结果：两组患者治疗前的PASI评分比较无差异(t=0.153， P＞0.05)；两组患者治疗后的PASI评分比较差异显著(t＝4.675，P＜0.05)；观察组患者治疗有效率为92%，对照组为75%；观察组不良症状发生率为20%，对照组为60%，两组比较有较大差异(x2=47.908，P＜0.05)。结论：窄谱中波紫外线联合复方甘草酸苷治疗银屑病相对于单纯使用窄谱中波紫外线照射治疗具有显著的治疗效果，可有效降低不良症状发生率，值得在临床上推广使用。