苄星青霉素治疗梅毒合并 HIV感染的疗效评价

摘要

Objective:To compare the therapeutic efficacy of benzathine penicillin in the treatment of pa-tients with syphilis without complicated with HIV infection and those co-infected with HIV. Methods:Ninety-five patients with syphilis were recruited from MSM population ( men who have sex with men) in VCT clinics and treated with benzathine penicillin 2.4 million units, weekly for 3 weeks. Thirty-one patients were co-in-fected with HIV ( group A) and 64 patients were not complicated with HIV infection ( group B) . Results:the total effective rate of RPR in the A group was 80.65%, 83.87%, 82.14% and 85.19%, while in B group was 81.25%、83.61%、86.89%、91.67% at month 3, 6, 9 and 12 months respectively, Which showed no statistical significance ( P>0.05) . Conclusion: Benzathine penicillin is effective in treating both patients with syphilis without complicated with HIV infection and those who are co-infected with HIV.%目的：比较苄星青霉素治疗合并HIV感染的梅毒和非合并HIV感染梅毒的疗效。方法：对来自VCT门诊男男人群合并HIV感染的梅毒患者( A组31例)和非合并HIV感染的梅毒患者( B组64例)均给予苄星青霉素240万U肌肉注射,每周1次,共3次,分别于治疗后的第3、6、9、12个月门诊随诊,比较两组患者的临床及血清学疗效。结果：治疗后的第3、6、9、12个月A组总有效率分别为80.65％、83.87％、82.14％和85.19％,B组分别为81.25％、83.61％、86.89％和91.67％,两组差异均无统计学意义( P>0.05)。结论：苄星青霉素治疗男男性行为人群中HIV合并梅毒感染和单纯梅毒感染的疗效相当。