Elafin与皮肤疾病

摘要

Elafin is an endogenous specific inhibitor of neutrophil elastase ( NE) which displays anti-prolif￣eration and anti-inflammatory properties by antagonizing NE. Elafin plays a significant role in multiple skin diseases such as melanoma, psoriasis, vasculitis, graft versus host disease, etc. In this paper the role of ela￣fin in some skin diseases is reviewed.%Elafin是中性粒细胞弹力蛋白酶( neutrophil elastase,NE)的内源性特异性抑制物,通过拮抗NE作用发挥其抗增殖、抗炎症等作用。 Elafin参与黑素瘤、银屑病、血管炎、移植物宿主病等多种皮肤疾病的发生发展。本文就Elafin在某些皮肤疾病中的作用加以综述。