银屑病患者外周血 TL1A 及其受体DcR3的表达

摘要

Objective: To detect the level of TL1A and its receptor DcR3 in the peripheral blood of pa-tients with psoriasis vulgaris. Methods: The level of serum L1A and its receptor DcR3 was detected by en-zyme linked immunosorbent assay ( ELISA) in 30 patients with psoriasis vulgaris and 30 healthy controls. Re-sults: The level of serum TL1A and its receptor DcR3 in the patients was (478.21± 231.18) pg/ mL and (638.31±310.73) pg/ mL, which were higher than those in healthy controls (125.67±82.85 pg/ mL and 45.16 ±111.52 pg/ mL)(P<0.05) and those in the patients of progressive stage were (584.91±298.52) pg/ mL and (860.41±402.78) pg/ mL, which were higher than those in the patients of stable stage (261.73±120.84 pg/mL and 67.34±225.16 pg/ mL)(P<0.05). The level of TL1A in the patients with psoriasis vulgaris was posi-tively correlated with DcR3 (P<0.05). Conclusion: The level of TL1A and its receptor DcR3 in the peripher-al blood of patients with psoriasis vulgaris was significantly increased and TL1A may play important roles in the progress of psoriasis vulgaris by combining with its receptor DcR3.%目的：：检测肿瘤坏死因子样配体1A(TL1A)及其受体 DcR3在寻常型银屑病患者外周血中的表达。方法：采用酶联免疫吸附试验(ELISA)检测30例寻常型银屑病患者及30名健康对照者血清中 TL1A 及其受体 DcR3的水平。结果：银屑病组外周血 TL1A 和 DcR3水平分别为(478.21±231.18)pg/ mL 和(638.31±310.73) pg/ mL,显著高于对照组的(125.67±82.85) pg/ mL 和(245.16±111.52) pg/ mL (均 P <0.05)。进行期患者 TL1A 和 DcR3水平分别为(584.91 ±298.52) pg/ mL 和(860.41±402.78)pg/ mL,显著高于静止期患者的(261.73±120.84)pg/ mL 和(467.34±225.16)pg/ mL (均P<0.05)；银屑病患者组外周血 TL1A 与 DcR3水平呈正相关。结论：银屑病患者外周血清 TL1A 及其受体 DcR3水平显著升高,TL1A 可能通过与其受体 DcR3结合参与银屑病的发生与发展。