The expression of Decoy Receptor 3 in peripheral Blood monocytes of Rheumatoid Arthritis Patient

摘要

To investigate DcR3 mRNA levels of peripheral blood monocytes in rheumatoid arthritis(RA), and analyzes the correlation between the DcR3 Levels of Peripheral Blood and the Disease Activity in Rheumatoid Arthritis Patient. The expression levels of DcR3 mRNA in peripheral Blood monocytes of 82 RA patients and 53 healthy controls were detected by real-time polymerase chain reaction. The expression levels of DcR3 mRNA of active stage in RA patients were higher than that of remission stage in RA patients and healthy controls(P<0.05); The correlationships between DcR3 mRNA levels and active renal score (DAS28)show positive correlation. The expression levels of peripheral blood DcR3 does significant increase in RA active patients and it is closely related with the activity of the disease which suggesting that DcR3 migh involved in the pathological process.