HCV-RNA联合肝功能主要指标对HCV抗体检测阳性者诊断意义的评价

摘要

Objective To explore the relationships between HCV antibody levels,HCV-RNA loading and liver function parameters in HCV antibody positive patients.Methods The serum HCV antibody,HCV-RNA loading and liver function parameters of 384 patients were analyzed. ResultsWhen HCV antibody level was 1.00 to 20.00 or more than 100.00,the positive rate of HCV-RNA in HCV antibody positive patients was significantly lower than that in the patients with HCV antibody level of 20.00 to 100.00. The difference was statistically significant (P<0.05). With increase of HCV-RNA loading,average levels of ALT,AST,GGT,TBIL,DBIL and IBIL increased. The difference was statistically significant(P<0.05). The level of ALP increased but not so obviously. Average levels of TP,ALB,GLOB changed little. Conclusion The combination of HCV antibody level,HCV-RNA loading and liver function parameters test conduce to a good understand of clinical diagnosis and treatment of HCV infection.%目的 探究HCV抗体阳性者中HCV抗体值、HCV-RNA载量及肝功能主要指标的关系.方法 回顾分析384名HCV抗体检测阳性者临床检测结果,研究HCV抗体值、HCV-RNA、肝功能主要指标间的关系.结果 HCV抗体值、HCV-RNA载量及肝功能主要指标三者密切相关,HCV抗体检测值在区间1.00~20.00,>100.00时其HCV-RNA检测阳性率低于抗体检测值在区间20.00~100.00时的HCV-RNA检测阳性率,差异有统计学意义(P<0.05).随HCV-RNA载量的升高,ALT、AST、GGT、TBIL、DBIL、IBIL检测值平均水平亦升高,差异有统计学意义(P<0.05);ALP水平有所增高但程度低于其他指标;而TP、ALB、GLOB平均水平基本无变化.结论 综合HCV抗体值、HCV-RNA载量及肝功能主要指标检测结果可更好地指导HCV感染的临床诊断及治疗.