联合检测降钙素原和超敏C反应蛋白对新生儿败血症早期诊断的临床价值

摘要

目的：探讨在新生儿败血症诊断中，联合检测降钙素原和超敏C反应蛋白的临床价值。方法收集2013年10月—2014年6月来该院治疗的新生儿105例，其中败血症组为47例败血症新生儿、对照组为58例健康新生儿，测定两组新生儿血清中降钙素原和超敏C反应蛋白的水平含量。结果在败血症组新生儿中，超敏C反应蛋白和降钙素原血清水平含量分别为(26．9±17．8)mg／L和(13．5±10．1)ng／mL，检测结果明显高于对照组水平含量，差异有统计学意义(P<0．05)。PCT、CRP对诊断新生儿早期败血症试验中，阴性预测值无显著差异(P＞0．05)；PCT敏感性、阳性预测值、特异性及准确度均高于hs—CRP (P<0．05)。结论在临床中新生儿败血症早期诊断中，检测新生儿降钙素原和超敏C反应蛋白的水平含量，参考联合两者能够更有效的对出评估。%Objective Study in diagnosis of neonatal septicemia, combined detection of clinical value of procalcitonin and high sensitivity C reactive protein. Methods From 2013 October-2014 year in June in our hospital 105 cases of neonatal sepsis group, including 47 cases of neonatal septicemia, control group was 58 healthy newborns, determination of content of reduced level of procalcitonin and high sensitivity C reactive protein in serum of two neonates. Results In neonatal sepsis group, high sensitive C reactive protein and procalcitoninserum level content respectively (26.9 + 17.8) mg /L and (13.5 + 10.1) ng /mL, the detection re-sult is significantly higher than the control group levels,with statistical significance (P<0.05). PCT CRP for the early diagnosis of neonatal sepsis, test, negative predictive value, no significant difference(P>0.05); PCT sensitivity, specificity, positive predictive value and accuracy were higher than that of HS-CRP (P<0.05). Conclusion In the clinical early diagnosis of neonatal sepsis, detection of neonatal drop levels of procalcitonin and high sensitivity C reactive protein, reference combination can be more effective on evaluation.