NT-proBNP检测联合GRACE评分对ACS患者预后的预测价值

摘要

Objective to explore the prognostic value of GRACE risk score and NT-proBNP complements on patients with ACS. Methods A total of 300 ACS patients in our hospital from June 2011 to March 2014 are selected. NT-proBNP level and GRACE risk score are measured for all of them when they in hospital. 300 patients are divided into two groups (group adverse cardiovascu-lar events and group without cardiovascular events), and retrospectively analyze the NT-proBNP level and GRACE risk score of the two groups. Results The NT-proBNP level of the group adverse cardiovascular events is higher than that of the group without cardiovascular events (P<0.05); the GRACE risk score of the group adverse cardiovascular events is higher than that of the group without cardiovascular events (P<0.05);the predictive ability of the GRACE risk score and the NT-proBNP level on patients with ACS is in the medium range, and there is no significant difference after six months being discharged from the hospital. By analyz-ing the ROC curve for GRACE risk score and NT-proBNP complements, the area is 0.852 (P<0.001), which indicates that the combination can improve the prognostic value for NSTE-ACS patients. Conclusion the GRACE risk score and NT-proBNP com-plements can accurate early risk assessment for ACS patients and it has unique clinical value.%目的：探讨NT-proBNP检测联合GRACE评分对ACS患者预后的预测价值。方法选取2011年6月—2014年3月来该院就诊的300例ACS患者，行NT-proBNP检测、GRACE评分。按不良心血管事件的发生将患者分为事件组与非事件组，回顾性分析两组患者 NT-proBNP、GRACE等数据。结果事件组NT-proBNP值仍高于非事件组（P＜0.05），事件组GRACE评分高于非事件组（P<0.05）；GRACE评分及NT-proBNP水平对于预测ACS患者预后的能力均为中等，且二者对NSTE-ACS患者出院后6个月后发生MACE事件的预测能力无统计学差异。而对GRACE联合NT-proBNP进行ROC曲线分析，曲线下面积为0.852(P<0.001)，表明二者联合可以增加对NSTE-ACS患者预后判断的能力。结论 NT-proBNP检测联合GRACE评分对ACS患者预后的预测可以更为准确评估ACS患者早期风险，有着独特的临床价值，也可以辅助临床医生对患者进行更科学的治疗。