弓形虫微线体蛋白研究新进展

摘要

微线体蛋白(microneme protein,MIC)是由位于弓形虫前端的微线体(microneme)分泌产生的,具有识别、黏附与侵染宿主细胞的性质.近年来研究结果证明,弓形虫的多种微线体蛋白在侵染宿主的过程中发挥重要作用,并且可以作为抗弓形虫病的疫苗候选分子.作者对目前研究较多的弓形虫微线体蛋白进行综述,为弓形虫疫苗的研究提供理论依据.%Microneme protein(MIC) is secreted by the microneme which is located in the front of the Toxoplasma gondii and has the feature of identifying,sticking and invading the host cell. The recent advances were reviewed in the studies of microneme protein (MIC) and it is concluded that MIC plays an important role during host cell invasion and it is potential candidate for the development of vaccines against toxoplasmosis. The article makes a literature review about the microneme protein of the Toxoplasrna gondii ,which providing the theoritical basis for the research of vaccines against toxoplasmosis.