微波辅助合成对羟基苯甲醚

摘要

以对苯二酚为原料、碳酸二甲酯（DMC）为甲基化试剂、聚乙二醇-400（PEG-400）为相转移催化剂，在微波辅助条件下合成对羟基苯甲醚，并通过1 HNMR 对其结构进行了确证。通过正交实验确定最优合成条件为：n（对苯二酚）∶n（DMC）∶n（K2 CO3）∶n（PEG-400）＝1∶8∶0.65∶0.40、反应温度95℃、反应时间35 min，在此条件下，对羟基苯甲醚的收率为76.40％。该合成方法避免了剧毒试剂的使用，安全性高，操作简单。%4-Methoxyphenol was synthesized by microwave-assisted method using hydroquinone as raw ma-terial,dimethyl carbonate(DMC)as methylating reagent,polyethylene glycol-400(PEG-400)as phase transfer catalyst.And its structure was confirmed by 1 HNMR.Through orthogonal experiment,the optimum conditions were obtained as follows:n(hydroquinone)∶n(DMC)∶n(K2 CO3 )∶n(PEG-400)was 1∶8∶0.65∶0.40,reac-tion temperature was 95 ℃,reaction time was 35 min.Under above conditions,the yield of 4-methoxyphenol reached 76.40%.This synthetic method avoids the use of poisonous reagent,which is simple and safe.