丙酮为溶剂Pd(OAc)2催化的Heck反应研究

摘要

A simple,convenient and effective Heck coupling reaction had been developed,which was a ligand-free,no external reducing agents,and Pd-catalyzed reaction. In the presence of catalytic Pd( Oac)2 with K2CO3 in acetone,an excellent chemoselectiv-ity to aryl C-I bonds had also been achieved in these coupling reactions of aryl iodides with various terminal olefins to afford trans-olefins exclusively.%研究了无需外加配体、在丙酮溶剂中Pd(OAc)2催化的Heck反应.得到的反应最优结果是:Pd( OAc)2(1 mol%)为催化剂,K2CO3(1.2 equiv.)为添加剂,以廉价易得的丙酮为溶剂,在100℃下各种碘代芳烃(1equiv.)可以顺利地与丙烯酸乙酯、苯乙烯和乙烯环已烷等烯基化合物(2 equiv.)发生催化Heck反应.同时,在该反应条件下,反应对芳烃的碳碘和碳溴键具有高度选择性,由此给出了一例合成不对称双烯烃化合物的应用实例.