环（L-色-L-脯）衍生物的合成及其抑菌活性研究

摘要

Four cyclo(L-Trp-L-Pro)derivatives were synthesized starting with methyl L-tryptophanate hydrochloride,aromatic alde-hydes and N-Fmoc-L-proline through Pictet-Spengler reaction,Schotten-Baumann reaction,NBS ring-opening and base catalyzed an-nelation. The structures were characterized by m. p. tests,NMR spectrum and elemental analysis. All compounds were shown good activity against bacteria according to the antimicrobial activities test.%以L-色氨酸甲酯盐酸盐、芳香醛和N-Fmoc-L-脯氨酸为原料，经过Pictet-Spengler反应、Schotten-Baumann反应、NBS开环反应、碱催化增环反应，得到4个环( L-色-L-脯)的衍生物，其结构均经过熔点测定、NMR、元素分析表征。在抑菌活性测试中发现，该类化合物对细菌有较好的抑制活性。