Synthesis of diketopiperazines containing prolinyl unit cyclo(L-prolinyl-L-leu-cine),cyclo(L-proIinyl-L-isoleucine) and cyclo(L-tryptophyl-L-proline)

摘要

Diketopiperazines cyclo(L-prolinyl-L-isoleucine) 4a,cyclo(L-prolinyl-l.-leucine) 4b and cyclo(L-tryptophyl-L-proline) 6 were prepared from their respective suitably protected amino acid derivatives by standard peptide chemistry.Cyclo(L-(4-hydroxyprolinyl)-L-phenylalanine) 3,4a and cyclo(L-prolinyl-L-tyrosine) S were tested for their antibacterial activity.