基于2-卤甲基-3-喹啉甲酸乙酯的反应研究进展

摘要

喹啉及其衍生物是一类重要的杂环化合物，许多具有生物活性的稠杂环化合物中都含有喹啉骨架。由2-卤甲基-3-喹啉甲酸乙酯合成多环或稠杂环化合物的研究进展还未见文献报道。为更好地了解这方面的研究动态，本文综述了近几年有2-卤甲基-3-喹啉甲酸乙酯参与反应的研究进展，主要涉及了2-氯（溴）甲基-3-喹啉甲酸乙酯与酚、胺、水杨醛和芳香醛等的一系列反应。%Quinoline and its derivatives are very important heterocyclic compounds,and many quinoline-containing heterocyclic-fused compounds have been found to exhibit potent biological activities. To the best of our knowledge,there is not any review sum-marizing the literature on the use of ethyl 2-(halogenmethyl)quinoline-3-carboxylate as the building blocks for synthesis of quino-line-bearing polycyclic heterocyclic-fused systems. As such,in order to cover the recent work in this aspect,and provide useful and up-to-date data for organic chemists,the present review focuses mainly on the reaction of ethyl 2-(halogenmethyl)quinoline-3-car-boxylate with phenols,amines,salicylaldehydes,aldehydes and so on.