盐酸氮卓斯汀治疗变应性鼻炎合并非小细胞肺癌的疗效分析

摘要

目的 探讨盐酸氮卓斯汀治疗变应性鼻炎合并非小细胞肺癌的疗效及对患者呼吸功能的影响.方法 回顾性分析我院收治的变应性鼻炎合并非小细胞肺癌患者114例,分为对照组和观察组.对照组给予西替利嗪片口服治疗,观察组给予盐酸氮卓斯汀治疗.对比两组患者的临床疗效、不良反应发生情况、炎性因子以及肺通气功能.结果 观察组患者的临床疗效显著优于对照组(P<0.05);治疗后,观察组患者咽喉肿痛、头晕嗜睡、肠胃不畅、鼻塞堵塞等不良反应发生率明显低于对照组(P<0.05);治疗前,两组患者炎性因子IL-6、CRP、TNF-α水平无明显差异(P>0.05),治疗后,观察组患者IL-6、CRP、TNF-α水平明显低于对照组(P<0.05);治疗前,两组患者的肺通气功能无明显差异(P>0.05),治疗后,观察组患者的肺通气功能明显优于对照组(P<0.05).结论 对变应性鼻炎合并非小细胞肺癌患者采用盐酸氮卓斯汀治疗,可显著提高临床疗效,降低炎性因子水平,增强呼吸功能.%Objective To investigate the efficacy of azelastine hydrochloride in the treatment of allergic rhinitis combined with non-small cell lung cancer and its effect on respiratory function. Methods The data of 114 patients with allergic rhinitis combined with non-small cell lung cancer admitted to our hospital were analyzed retrospectively. The patients were divided into control group and observation group. The patients in control group were treated with cetirizine tablets orally and the patients in observation group were treated with azelastine hydro-chloride. The clinical efficacy, adverse reactions, inflammatory factors and pulmonary ventilation function were compared between the two groups. Results The clinical efficacy of the observation group was significantly better than that of the control group (P<0.05). After treat-ment, the patients in the observation group had significantly lower incidences of swollen sore throat, dizziness, drowsiness, gastrointestinal disorders, nasal obstruction and other adverse events than those in the control group (P<0.05). Before treatment, there was no difference in the levels of IL-6, CRP and TNF-α between the two groups (P>0.05). But after treatment, the levels of IL-6, CRP and TNF-α were significantly lower in observation group than in control group (P<0.05). There was also no significant difference in pulmonary ventilation function between the two groups before treatment (P>0.05), and the pulmonary ventilation function of the observation group was significantly better than that of the control group after treatment (P<0.05). Conclusion Azelastine hydrochloride treatment for allergic rhinitis patients with non-small cell lung cancer can significantly improve the clinical efficacy, reduce inflammatory factor levels, and enhance the respira-tory function of patients.