香菇多糖注射液联合鸦胆子油乳注射液姑息治疗晚期消化道恶性肿瘤的近期疗效分析

摘要

Objective To analyze the near-term efficacy and safety of lentinan injection plus javanica oil emulsion injec-tion palliative treatment for patients with advanced gastrointestinal cancer. Methods A randomized 85 patients diagnosed with advanced gastrointestinal cancer were divided into control group and observation group. 42 patients in the control group were given palliative treatment with javanica oil emulsion injection. 43 patients in the observation group were given lentinan injection plus javanica oil emulsion injection. 21d for a course and after three courses of treatment, the short term efficacy, quality of life and adverse reactions were observed and compared between the two groups. Results The overall remission rate of the observa-tion group had no statistical difference with that of the control group (20.93% VS 19.05%, P>0.05). The disease control rate of the observation group was also significantly higher than that of the control group (55.81% VS 33.33%, P<0.05). The life quality of the observation group was significantly higher than that of the control group (67.44% VS 42.86%, P<0.05). The major ad-verse events of both groups were neutropenia, gastrointestinal reactions, anemia, liver function abnormalities, but the incidence of adverse reactions was significantly lower in the observation group than in the control group (P<0.05). Conclusion The Lentinan injection combined with javanica oil emulsion injection palliative treatment had better curative effect than javanica oil emulsion injection alone on advanced gastrointestinal cancer. It could significantly improve the quality of life of patients and reduce toxicity, and is worthy of further study.%　　目的分析香菇多糖注射液联合鸦胆子油乳注射液姑息治疗晚期消化道恶性肿瘤的近期疗效和安全性。方法随机将85例确诊晚期消化道恶性肿瘤患者分为两组，对照组42例，给予鸦胆子油乳注射液姑息治疗，观察组43例，给予香菇多糖注射液联合鸦胆子油乳注射液姑息治疗，21 d为1个疗程，治疗3个疗程后观察和比较两组的近期疗效、生存质量和不良反应。结果观察组的治疗总缓解率与对照组比较，差异无统计学意义（20.93％ vs.19.05％, P>0.05）；观察组的疾病控制率（55.81％ vs.33.33％）和生存质量（67.44％ vs.42.86％）均明显高于对照组（P<0.05）；两组患者的主要不良反应为白细胞减少、胃肠道反应、贫血、肝功能异常等，观察组不良反应的发生率明显低于对照组（P<0.05）。结论香菇多糖注射液联合鸦胆子油乳注射液姑息治疗晚期消化道恶性肿瘤患者疗效较单用鸦胆子油乳注射液更好，能够明显提高患者的生存质量并降低毒副作用。